Uji Efek Analgetik Ekstrak Daun Prana Jiwa (Euchresta horsfieldii) Terhadap Mencit Jantan (Mus musculus)

This study aims to determine the effect and concentration of prana jiwa
leaf extract as an analgesic for male mice. This study used 15 mice
divided into 5 groups, each of which was a negative control Na. CMC,
prana soul leaf extract 0.3% w/v, 0.6% w/v, 0.9% w/v, and mefenamic
acid. The analgesic effect of prana soul leaf extract was carried out by the
chemical induction method, namely the peritoneal test (writhing reflex
test). The writhing reflex test method is used for non-narcotic analgesic
testing. The principle of this method is to observe the amount of writhing in
mice that occurs as a result of giving 0.5% v/v acetic acid induction by
intra-peritoneal (IP) administration. This acetic acid solution is used as a
trigger for pain in the form of writhing in mice. The results showed that the
prana jiwa leaf extract 0.3%, 0.6% and 0.9% w/v can provide analgesic
effects in mice. Prana Jiwa leaf extract with a concentration of 0.9% w/v
provided a more effective analgesic effect than a concentration of 0.3%
and 0.6% w/v, but not as effective as mefenamic acid 0.2% as a positive
control.
Keywords: Analgesics, Extracts, Prana Jiwa and Mice